Abstract:Building regional technology innovation center of global influence is increasingly becoming the major strategies to enhance national comprehensive strength and deal with a new round of scientific and technological revolution for many countries and regions.This paper summarizes the construction of foreign coastal science and technology innovation centers such as the New York Bay, San Francisco Bay, Tokyo Bay, as well as the construction of domestic coastal science and technology innovation centers such as Guangdong-Hong Kong-Macao Greater Bay Area, and condenses their common practices and measures. By drawing on the experience of the construction of these coastal science and technology innovation centers, the top-level design of Qingdao's technological innovation center of global influence has been carried out, and the main line, innovative element layout and specific implementation path have been proposed. The suggestions are expected to provide decision support for Qingdao and other domestic coastal cities to build regional scientific and technological innovation centers with global influence.