Abstract:The long-term interest game among the federal government, university administrators and researchers promotes the reform and improvement of the indirect cost reimbursement system. Based on the core characteristics of different historical periods, the indirect cost reimbursement system has experienced five stages: Decentralized Management, Unified Negotiation, Accurate Accounting, Supervision and Accountability, and Effective Implementation. The general trend of institutional reform shows the characteristics of institutional management from "decentralization" to "centralization", cost accounting from "roughness" to "delicacy", and determination mechanism from "complexity" to "simplicity". The idea of "cost sharing" runs through the whole system reform, which indicates that the essence of "cost sharing" is incomplete cost reimbursement, and colleges and universities need to share part of indirect costs.