Abstract:The paper to promote the construction of the the Belt and Road Initiatives and deepen the international scientific and technological cooperation between China and the five Central Asian countries, and provide objective and reliable scientific research competitiveness, discipline development analysis and scientific and technological cooperation proposals for the five Central Asian countries. According to the report of the Ministry of Science and Technology of the five Central Asian countries, the international organization special report, the Web of Science database, the Incics database and the ESI database, using the bibliometric method, supplemented by the social network analysis method, analyzes the five Central Asian countries from the aspects of technology input and output. Scientific research competitiveness, key research disciplines and dominant disciplines, explore the changes in international scientific and technological cooperation before and after the “One Belt, One Road” strategy; based on the science and technology policies of the five Central Asian countries, sum up and summarize the priority industries of each country. The study found,The scientific and technological competitiveness of the five Central Asian countries is uneven, and the development of disciplines has its own emphasis. The policies of various countries have adjusted the priority development direction of the industry. China and the five Central Asian countries should increase cooperation in basic disciplines such as physics, mathematics, and chemistry to achieve mutual development of each other; strengthen cooperation in clinical medicine, environmental ecology, animal and plant science, and other areas to enhance China"s scientific and technological influence. We should seize the opportunities of industrial adjustment in Central Asian countries, promote scientific and technological cooperation in high-tech fields such as agriculture, environmental protection, light industry, energy, and information and communication; adopt nationally differentiated choices to carry out scientific research cooperation to improve the cooperation between China and Central Asian countries. The efficiency of scientific and technological cooperation.