Abstract:The progress of science and technology promotes the vigorous development of economy, while the growth of science and technology industry depends on the advancement of finance. This paper selects indexes based on several principles of index selection and conducts factor analysis to meet the input-output index requirements of DEA model. Malmquist index can analyze the changes of multi-period decision-making units and eliminate the factors of technological progress. Compared with cross-sectional data, it can obtain more accurate results. In this paper, Malmquist index and BCC-DEA model are introduced to analyze the multi-period technology and finance integration efficiency of various provinces and cities in China, Guangdong Province and various prefecture-level cities in Guangdong Province. The study found that the development level of technology and finance in Guangdong Province is in the leading position in the country, but the development of technology and finance in Guangdong Province is unbalanced. It is suggested that Guangdong Province formulate characteristic technology and finance development strategies according to its own situation and strengthen the training of talents in technology and finance.