Abstract:[Purpose/Meaning] In view of the fact that China"s current technology supervision subjects are relatively single, lacking top-level design and loosely structured system, it aims to build a synergy concept from the perspective of multi-agents to build a coalition of science and technology supervision entities, and then to enhance supervision. Effectiveness. [Method/Process] Combine system theory and synergy theory, explore the construction of the alliance from the local to the whole path, and guarantee the operation and improvement of the alliance from four aspects: policy, technology, law and supervision. [Results/Conclusions] The construction of the technical fund supervision subject alliance including element level, organization level, operation level, supervision operation level and target level. Under the guidance of the target, different levels are better realized in the process of interaction. The entire league runs.