Abstract:In recent years, China's R&D investment in high-tech industries has grown substantially. while the number of innovative outputs (such as patents) in some economically developed cities has increased significantly, and technological output has become increasingly localized. But what factors determine the impact of technological output across geographical boundaries? Based on patent data from 1999 to 2014, we used 764 Chinese biotechnology patents for empirical analysis. We measured the six patent characteristics of these patents (Sci-Tech Relation, Tech search breadth, Research collaboration, Patent claim, Patent scope, Patent height). The empirical results show that Research collaboration has a negative impact on knowledge localization knowledge spillover; while scientific knowledge and localized knowledge spillovers present U-shaped relationship, that is, the more scientific papers cited by patents, the stronger the interaction between science and technology. As a result, the probability that a subsequent patent will produce breakthrough innovation will be greater, and the requirement for the inventor's absorptive capacity and geographic proximity will be higher, and thus the knowledge diffusion will be more localized. This finding is important for local government innovation policies, and local governments often want to increase the localization of knowledge spillovers to maximize the benefits of policies within their jurisdiction.