Abstract:The transformation of scientific and technological achievements in colleges and universities is an important part of China"s scientific and technological innovation system. Therefore, from the theoretical perspective of knowledge production mode 3, this paper proposes new changes in the transformation concept, cooperation path and management mechanism of the transformation mode of scientific and technological achievements of colleges and universities. By analyzing the status quo of the transformation mode of scientific and technological achievements in colleges and universities in Guangdong province, it is found that there are a series of practical problems in the transformation practice in Guangdong province, such as materialized achievement transformation idea, closed achievement transformation path and single management mechanism of achievement transformation. And then proposed countermeasures based on Mode 3 theory.