Abstract:There are strong reciprocity features in the human socio-economic system. Reciprocity preference is the complement and transcendence of rational preference. Industry-University is a basic innovation strategy in China, but its efficiency is still low. The lack of industry-university efficiency stems partly from the extreme egoistic thoughts and behaviors of the participating subjects. Reciprocity preferences and industry-university collaboration have a natural fit. Reciprocity collaboration between industry-university collaboration can reduce transaction costs, reduce adverse selection and moral hazard, and mitigate conflicts in profit distribution. Chinese enterprises and universities lack not only the understanding of the value of reciprocal collaboration, but also the necessary skills and experience of reciprocal collaboration. Reciprocal collaboration can be carried out from two levels of economics and management, which not only enriches the theory of industry-university synergy, but also improves the level of industry-university synergy.