Abstract:Based on the provincial panel data of 30 provinces in China from 2006 to 2016, this paper used the two-way fixed effect model and IV-GMM model to measure the impact of population aging on technological innovation, and included spatial factors for robustness test. The results show that there is a significant inverted u-shaped curve relationship between population aging and technological innovation in China, and population aging will indirectly affect technological innovation through two mediation effect, namely human capital level and capital-labor endowment. At the same time, scientific and technological innovation has a significant positive spatial spillover effect, through which the population aging can have an indirect impact on scientific and technological innovation in other provinces. Therefore, in the aging period, the government should focus on improving the level of human capital, promoting the re-employment of the aging population, improving the efficiency of resource allocation and promoting regional collaborative innovation.