Abstract:For science and technology innovation corridor, “entrepreneurship is more important than innovation”, and it is also necessary to build an integration channel from R D platform to production platform. Based on the city level panel data of 2005-2017, taking the technological innovation efficiency of the cities involved in the Guangzhou Shenzhen Hong Kong and Macao science and technology innovation corridor as the explanatory variable, the article creates respectively the threshold models of “expansion” of the corridor, and empirical analysis the impact of R D investment on technological innovation efficiency. The research shows that the threshold value of “expanded” corridor is lower, and all kinds of innovation subjects can achieve the original science and technology innovation efficiency with lower R D investment. After exceeding the threshold, the “expanded” corridor has higher coefficient elasticity, which is more conducive to the accelerated development of scientific and technological innovation. The control variables of per capita GDP and proportion of total industrial output value to regional GDP are significant after “expansion”, and positively related to the efficiency of scientific and technological innovation.