Abstract:Scientific research cooperation generally refers to a scientific research cooperation network formed by participants in science and technology activities based on scientific and technological goals. The research cooperation relationship paradigm can be characterized as a keyword co-occurrence network, a unit cooperation network, and a scientific research talent cooperation network. By constructing a "technical hotspot-unit-key talents" scientific research cooperation selection framework, can effectively advance research cooperation options and anticipate the future direction of cooperation.. Based on the national nanotechnology science and technology report in the past 10 years from 2006 to 2018, comprehensive literature measurement and social network analysis methods are used to analyze and visualize the network structure of scientific research cooperation in the field of nanotechnology. The study found that the choice of research cooperation under the relationship paradigm can be carried out at different levels. Based on the advantages of technical knowledge, each unit chooses to cooperate with the units related to its research hotspots and needs. Technical hotspots have become an important basis for cooperation choice. Key talents are particularly important, not only to establish connections with highly-centered scientific research talents, but also to expand cooperation with low-limit “structural hole” talents to promote interdisciplinary research.