Abstract:On the basis of the Web of Science core database, this paper makes use of the VOSviewer and ITGInsight literature analysis tools to analyze the general situation analysis, regional distribution analysis, regional cooperation network analysis, institutional cooperation network analysis, subject distribution and hot spot identification of the cooperative papers between the institute of Chinese Academy of Sciences(CAS) and local scientific research institutions in six provinces of central China. The research shows that among six provinces of central China, sci-tech cooperation in Anhui province is Outstanding, its scientific research strength is strong and its academic influence is high. However, scientific and technological cooperation in six provinces of central China is obviously insufficient, and integration has not yet taken place. Finally, based on the results of statistical analysis, the paper puts forward some suggestions:Strengthen the top-level design so as to straighten out the interaction mechanism between CAS institutions and local scientific research institutions in six provinces of central China;Strengthen systematic planning and straighten out the internal scientific research management mechanism of CAS institutions in six provinces of central China;Further promote the development of regional innovation systems.