Abstract:Universities and local governments to build high quality new R&D institutions is an important way to achieve technological innovation. Existing research is short of the systemic research on the construction of building universities and local governments high quality new R&D institutions. In this paper,we use fs/QCA to conduct configuration analysis of 19 new R&D institutions of universities and local government building based on Resource-Based View. Study found that:(1)the local industrial base, the brand of colleges and universities, the support of government and universities resources can not alone constitute the necessary conditions of a high quality R& D institutions;(2)there is three paths of driving high quality universities and local government building new R&D institutions:1)good industrial foundation, local colleges and universities high brand awareness can obtain better development;2)under the condition of the low brand awareness of universities,the high support of resources can obtain better development;3) local good industrial foundation and resources to support high can obtain better development. The conclusion of this paper is conducive to deepen the rational understanding of the complex relationship between multiple factors behind the high-quality development of Chinese universities and local governments new R&D institutions.