Abstract:To construct an innovative and entrepreneurial ecosystem of new technology application for Higher Vocational colleges is to achieve the talents cultivation objectives of higher vocational education under scientific & technological revolution and industrial transformation on the first round and to help our nation implement innovation-driven strategies as well as provides our locals with vital references and approaches to promote industrial upgrading. This paper analyzes the educational concepts of innovation and entrepreneurship with new technology application , based on this, has also constructed the innovative and entrepreneurial ecosystem model of new technology application and discusses the basic element composition of the innovative and entrepreneurial ecosystem as well as the interrelationships between composition elements. In closing, this paper induces and summarizes the practical effects of innovation and entrepreneurship with new technology application as the orientation, and puts forward pondering questions and suggestions in terms of major clusters, curriculum systems, management mechanisms, community activities, globalization strategies and competition systems from 6 aspects.