Abstract:Based on the theoretical analysis of the agglomeration, interaction effect and innovation ecosystem of the University City, Facing the new trend of technological innovation and industrial upgrading in Guangzhou, this paper will clarify the internal mechanism of innovation and entrepreneurship advantageous resources and its ecosphere around Guangzhou University City from the perspective of innovation value chain. It will build a whole chain innovation incubation and cultivation system of "Pre incubator - Incubator - Accelerator - Industrial Park" around Guangzhou University city, with the process from "Creative idea - Entrepreneurship programs - Start-ups - Industrial Cluster" to the realization of high-tech industrialization. By reforming innovation mechanism, establishing cooperative governance system of innovation subjects and incubation financial service system, and promoting the international layout of innovation incubation, it will construct the operation mechanism of innovation and entrepreneurship incubation in the whole process from the core upgraded to the external core expanded of innovation and entrepreneurship ecosphere around Guangzhou University City. It will systematically plan a new path of regional innovation development, promoting the better integration of innovation chain into industrial chain, expanding the radiation scope of the incubation chain of scientific and technological innovation, and solving its Value Dilemma. It will provide high quality technical support for industrial transformation and economic development in Guangdong-Hong Kong-Macao Greater Bay Area.