Abstract:The optimal allocation and effective utilization of science and technology resources have become an important strategic means for the government to support science and technology innovation. Among them, the allocation mechanism of science and technology resources, as one of the core issues in the management and operation of regional science and technology innovation system, has been paid more and more attention by science and technology management departments. Based on the synergistic perspective, this paper constructed the analysis framework of science and technology resources in Jing-Jin-Ji region, and established the ‘five-in-one’ optimal allocation system of subject, space, environment, market and service for Jing-Jin-Ji science and technology resources. In addition, based on the current problems in science and technology resource allocation in Jing-Jin-Ji region, the countermeasures and suggestions were put forward from different aspects including industry-university-research cooperation, space optimization of science and technology resources, marketization of science and technology achievements, service linkage of science and technology innovation, synergistic improvement of the innovation environment.