Abstract:The profit distribution mechanism of the transformation of scientific and technological achievements is the key problem that affects the development and innovation of science and technology. The unfair distribution of the profits from the transformation of patent achievements is easy to frustrate the enthusiasm of all parties involved in the transformation, thus losing the power to continue scientific and technological innovation. Based on the mathematical analysis of the current situation of the transformation of the patent results of the new R & D institutions in Guangdong Province, this paper finds out that the transformation of the intellectual property of the new R & D institutions in Guangzhou is mainly restricted by the factors such as the restriction of the construction subject's own culture, the diversification of the intellectual property investment, and the shortage of the professional personnel engaged in the transformation of the scientific and technological achievements The factor of power transformation is the incentive and distribution mechanism of rights and interests of all parties within the organization, and the suggestion of building multi-dimensional linkage among all subjects and balancing the incentive and distribution of patent achievements transformation is put forward.