Abstract:The establishment of innovation ecosystem is conducive to the exchange and sharing of resources across producer service and manufacturing industry, and to the synergy agglomeration between them. The niche suitability model is used to measure the level of suitability of regional innovation ecosystems in 30 provinces and cities from 2010 to 2018, and the sys- GMM and mediation effect methods are used to empirically study the influence of the suitability of regional innovation ecosystems on the synergy agglomeration of producer services and manufacturing industry. The results show that the niche suitability of China's regional innovative ecosystems is characterized by regional imbalance. The higher the niche suitability of the regional innovation ecosystem is, the more conducive it is to promote industrial synergy, and the mediating effect of technological innovation in this process is significant. Specifically, innovation community has a significant negative effect on industrial synergy agglomeration, while the effect of innovation resources and innovation environment is not significant. Innovation capability has a positive effect on industrial synergy agglomeration. This paper can provide beneficial enlightenment for the construction of industrial innovation ecosystem of producer service and manufacturing industry.