Abstract:Venture capital is the important part of financing market. The regional agglomeration not only reflects the regional industrial innovation vitality, also plays an important guiding role in the flow of innovation and entrepreneurship resources. Based on the data of Pearl River Delta City Group between 2012 year and 2018 year, this paper analyzes the regional agglomeration distribution and effect of venture capital with the method of location entropy and spatial econometrics,showing that: (1) Venture capital in the Pearl River Delta is mainly concentrated in Shenzhen and Guangzhou, followed by Dongguan, Zhuhai and Zhongshan, and the lowest in Jiangmen, Zhaoqing ,Foshan and Huizhou; (2)The cluster of venture capital investment has significant spatial correlation, showing a two-stage pattern from the spatial correlation increasing year by year to the current decline and tends to be stable; (3) Regional per capita GDP, scale of high-tech enterprises ,scientific and technological innovation talents have significant positive correlation with venture capital, while regional innovation expenditure scale has significant correlation with venture capital, showing both positive and negative situation.