Abstract:In order to show the status quo of Hong Kong and Macao participating in the construction of the “Belt and Road”, and to promote the participation of Hong Kong and Macao in scientific and technological innovation(STI) cooperation, this article conducts a qualitative and quantitative analysis of the three aspects of Hong Kong and Macao’s participation in the “Belt and Road” construction, the opportunities that can be seized, and the existing difficulties. These are based on the information on the “Belt and Road Portal” and relevant papers from Hong Kong and Macao key laboratories included in the Scopus database. The study found that Hong Kong and Macao actively participate in the business cooperation of the "Belt and Road" construction, but relatively little cooperation in STI is involved, and most of them are concentrated in the advantageous areas of Hong Kong and Macao. The strong support of the state, the attention of the government of the Special Administrative Region, the advantages of Hong Kong’s professional services and Macao's China and Portuguese-speaking countries platform are major opportunities for Hong Kong and Macao to participate in the construction of the "Belt and Road". At present, both Hong Kong and Macao are facing different degrees of difficulties. In order to break through the status quo of Hong Kong and Macao participating in the construction of the “Belt and Road”, this article proposes to take advantage of Hong Kong's professional services and use Macao as a medium to develop cooperation between China and Portuguese-speaking countries to promote Hong Kong and Macao to participate in the “Belt and Road” STI cooperation.