Abstract:The essence of the driving mechanism of high-quality development of regional economy is the interactive relationship embedded in the regional socio-economic system, which is formed around how to solve the three core problems of the current unbalanced economic development, structural imbalance and the lack of development impetus. Empirical analysis of factor interaction based on VAR model and measurement of system synergy effect in coupled coordination degree model, it reveals the function mechanism of technology, talent, capital and other innovation elements and corresponding driving mechanism on high-quality development of regional economy, and reflects the actual predicament and influencing factors of the implementation of innovation-driven strategy to promote the high-quality development of regional economy. In the new stage of development, it is necessary to promote the synergy between regional innovation drive and high-quality economic development by improving the regional innovation system to speed up the transformation and industrialization of scientific and technological achievements, developing higher education to promote the upgrading of human capital structure and the quality of knowledge creation and supply, improving a modern financial system to enhance the ability to serve the real economy and innovation driven development, and accelerating the establishment of an innovation-driven development model that integrates innovation chains, education chains, talent chains, capital chains and industrial chains.