Abstract:To further promote the integrated development of culture and science and technology is an important measure to promote the implementation of the Guangdong-Hong Kong-Macao Greater Bay Area strategy in the new era and to participate in international cultural, scientific and technological cooperation at a high level.The establishment of a state-level demonstration base for the integration of culture and science and technology is becoming a powerful engine for industrial transformation and upgrading in the Greater Bay Area, and creating a sound ecosystem for the integrated development of culture and science and technology.The integration of culture and technology in Guangdong, Hong Kong and Macao Greater Bay Area is characterized by high starting point, high technology and high efficiency. Its driving force is derived from cross-border integrated development, systematic policy support from governments at all levels, and rapid growth of cultural needs in the Greater Bay Area.The future development direction is the content production digitalization, the content dissemination platform, the credibility guarantee decentralization.In the process of building the Cultural Bay Area, we can choose the three paths of science and technology finance, culture and technology integration demonstration base, and inter-disciplinary talent training to enhance the level of cultural and technological integration, promote mutual learning between culture and science and technology, and create a road of cultural and technological integration with Chinese characteristics.