Abstract:The Technology Innovation Center is a newly established science and technology innovation platform in the country, and it is one of the key directions for the establishment of a national science and technology major project. Based on the existing scientific and technological innovation platforms, analyze the current and domestic research status of the Technology Innovation Center. Based on major science and technology projects of large aircraft, research the establishment mode, principles, layout and mechanism of the National Technology Innovation Center, build a construction model from three aspects of basic ability, professional ability and system ability, and explore the construction mode of technology innovation center based on major science and technology projects. It provides suggestions from five aspects: the functional positioning, the top-level planning, the construction layout, the transformation of results, and the operating mechanism. Providing method support and decision-making reference for the construction of a new technological innovation center.