Abstract:In the era of knowledge economy, innovative infrastructure has become an important strategic resource for the country to participate in global competition. But how does the innovation infrastructure affect innovation output? This article first establishes the theoretical framework and evaluation index system of innovation infrastructure through qualitative analysis. Based on the data from 2007 to 2017, this paper analyzes the correlation between innovation infrastructure and innovation output of 31 provinces and cities in China by building a mathematical model.Then we will further analyze the impact of each indicator of innovation infrastructure on innovation output and the regional differences of correlation degree.The results show that innovation infrastructure is strongly correlated with innovation output.There is a significant regional difference in the correlation between the innovation infrastructure and innovation output of each province. The eastern region has a relatively high level of innovation output due to the relatively complete innovation infrastructure. While the relatively backward innovation infrastructure in the western region has severely restricted the increase in innovation output. The study provided important evidence for how to develop the construction of innovation infrastructure and promote innovation output in the future.