Abstract:Based on the panel data of 30 provinces (districts/cities) in Mainland China from 2009 to 2018, the spatial Durbin model was used to study the influence of regional innovation factor agglomeration (innovation personnel agglomeration and innovation capital agglomeration) on the high-quality economic development, and the moderating effect of financial development on the relationship between them. The results show that there are significant positive spatial spillover effects at the high-quality development of China's economy, and the development levels of eastern, central and western regions differ greatly. Innovation personnel agglomeration and innovation capital agglomeration have a positive direct effect on the high-quality economic development of the region, but have an inhibitory effect on the high-quality economic development of neighboring regions. Financial development can positively regulate the relationship between innovation personnel concentration, innovation capital concentration and the high-quality economic development of the region, but it has no obvious regulating effect on the relationship between innovation factor concentration and the high-quality economic development of neighboring regions. Labor supply, urbanization level and informatization can all promote high-quality economic development, and government intervention has a restraining effect on high-quality economic development.