Abstract:It is basic guarantee that the policies on promoting regional collaboration innovation in Great Bay Area of Guangdong-Honkong-Macao, and it needs synergetic and systematic; At present, the relative policies on promoting regional collaboration innovation in Great Bay Area of Guangdong-Honkong-Macao, scatter among all kind of the government documents. It is difficult to use, because of these are from different departments and regions, and there is wide variation on the orientation and strength of policies among regions. It is crying needs to formulate more systematic or synergetic specialized polices during promoting the regional collaboration innovation in the Great Bay Area of Guangdong-Honkong-Macao. By this mean of analyzing on the changing of the policies environment and sorting the relative government documents, and evaluating the relative policies on promoting regional collaboration innovation in Great Bay Area of Guangdong-Honkong-Macao; Based theories of regional collaboration innovation, building the polices system of regional collaboration innovation in Great Bay Area of Guangdong-Honkong-Macao, namely “1+4+2”, and its issues of these polices system.