Abstract:Under the background of innovation-driven development strategy, the construction of scientific research institutions in Guangdong Province has accelerated, but there are still problems such as unclear positioning and chaotic layout. In order to promote scientific research institutions to better serve scientific and technological progress and the economy and society, this paper first quantitatively evaluates the innovation capabilities of scientific research institutions in various cities in Guangdong Province, and then combines the Wilson model and the field strength model to measure the impact of scientific research institutions on scientific research institutions. The radiation effect of cities with weaker innovation capabilities. The study found that: the innovation ability of scientific research institutions in the cities of Guangdong Province is quite different; the cities affected by the radiation of innovation ability have large differences in the ability to accept radiation effects. Furthermore, based on the research results, policy recommendations are put forward to optimize the spatial layout of scientific research institutions in Guangdong Province and promote the coordinated development of regional scientific and technological innovation.