Abstract:The knowledge network structure and boundary-spanning search are the front end factors of breakthrough innovation. The structural characteristics of knowledge network and the degree of boundary-spanning search have different impacts on the breakthrough innovation. Using data on patents in the field of artificial intelligence technology in the United States, the researchers build a knowledge network of 243 organizations, then empirically analyzed the influence of Knowledge Network Centralization, knowledge network structure hole and boundary-spanning search on organizations. The empirical analysis has verified the following hypotheses: The Centralization and structure hole of knowledge network are positively correlated with the breakthrough innovation performance. The centralization and structure hole of knowledge network are positively correlated with boundary-spanning search. The boundary-spanning search can positively affect breakthrough innovation and present partial mediation effect in the relationship between knowledge network structure and breakthrough innovation performance.