Abstract:Driven by factors, technologies and systems, collaborative innovation will evolve from the primary stage to the advanced stage, forming a regional collaborative innovation community. Technology driven comes from the rational allocation of innovation elements in factor driven, and technology driven has become the basis of supporting system driven. Based on the Haken Model, this paper analyzes the driving factors of collaborative innovation of nine cities in the Pearl River Delta urban agglomeration during the 19 years from 2000 to 2010 and 2011 to 2018. The results show that, under the background of speeding up the construction of international science and technology innovation center in the Guangdong-Hong Kong-Macao Greater Bay Area, the level of collaborative innovation in PRD urban agglomeration has been continuously improved. The main driving factors of collaborative innovation have changed from factor driven to technology driven. Innovation factor input and innovation efficiency have become the main driving forces of industrial synergy. Shenzhen and Guangzhou play an important role in the process of collaborative innovation of PRD urban agglomeration.