Abstract:The key to the high-quality economic development of the Guangdong-Hong Kong-Macao Greater Bay Area is to reconstruct the industrial innovation ecosystem characterized by "destructive creation" in cooperation with Hong Kong and Macao.Based on the field investigation and the relevant academic research results, the strategic orientation and path choice of the ecological reconstruction of industrial innovation in the Greater Bay Area are abstracted.Study shows:Should perfect the "knowledge economy - players - commercial economy" for the circulation of ecological reconstruction mechanism,based on the global production system, the national system of innovation and management,the industrial cluster innovation ecological value network should be built up,in order to build the whole public body which have the height of the industry and innovation synergy cooperation community, double drive technology and market.It should achieve a strategy choice which drive the industry development from the "creative destruction" to the "creative destruction" shift in Guangdong-Hong Kong-Macao Greater Bay Area.Further, the paper puts forward relevant policy Suggestions from the aspects of construction of application circle of science and technology industry and improvement of cooperation system and mechanism.