Abstract:The advancement of technological innovation drives the economic development of the bay area. This paper compares and summarizes the development of scientific and technological innovation systems in New York Metropolitan area,San Francisco Bay Area,Greater Tokyo Area and Guangdong-Hong Kong-Macao Greater Bay Area from five aspects of R D investment, innovation entities, innovation policies, industrial structure and open innovation. Finally, suggestions are made for the construction of the Guangdong-Hong Kong-Macao Greater Bay Area"s scientific and technological innovation system in terms of R D support, coordinated development of cities, cooperation of innovative entities, and talent introduction.