Abstract:Under the background of "anti globalization" and even "de Sinicization" under the influence of the game between China and the United States and the impact of epidemic situation, it is of great strategic and practical significance to establish a Research Institute for large enterprises in Guangdong to ensure the security of supply chain. This paper studies the function orientation and main function of Guangdong large-scale manufacturing enterprise research institute, discusses the thinking and operation mechanism of Establishing Enterprise Research Institute, and provides countermeasures and suggestions for Guangdong large-scale enterprise research institute. The results show that: we should create a number of national and provincial research institutes; sort out the list of short board technologies and key technology bottlenecks of key industries to support enterprise research institutes to tackle key problems; build a diversified and multi-level investment mechanism to provide key support to the research institutes undertaking the core technology research on the list; and make plans around the goals of ensuring the security of the supply chain, strengthening the industrial chain and deploying the innovation chain To attract and gather high-end talents for the construction of large enterprise research institutes.