Abstract:Regional collaborative innovation is an important engine and kinetic energy to implement the national innovation-driven development strategy, and it is of great significance to conduct in-depth research on it. Based on the construction of the internal mechanism and logical framework of multi-dimensional proximity, spatial correlation and regional collaborative innovation performance in the province, this paper uses spatial econometric analysis methods to conduct empirical tests on the panel data of 25 collaborative development zones in the province from 2004 to 2019. . The study found that geographic proximity, economic proximity, technological proximity, and institutional proximity in multi-dimensional proximity all have a significant impact on regional spatial associations, while cultural proximity has no significant impact on regional spatial associations; meanwhile, regional spatial associations It also has a significant positive impact on the performance of regional collaborative innovation in the province. The spatial correlation of innovation subjects and the interregional flow of innovation elements have effectively improved the performance of regional collaborative innovation in the province. In the case of changing the measurement method of multiple variables in the model, the results of the study are robust. The research conclusions of this paper have certain enlightenment significance for comprehensively revealing the internal mechanism and influencing factors of regional collaborative innovation performance in the province and improving the performance of regional collaborative innovation in the province.