Abstract:The proximities among regions have great impact on the inter-regional industry-university collaborative innovation. This study explores the mechanism of the impact of economic proximity, institutional proximity, geographical proximity and cognitive proximity on inter-regional industry-university collaborative innovation, and proposes four hypotheses accordingly. The data consists of a set of co-invention patents authorized by 31 provinces between 2001 and 2018 in China, The fixed-effect negative binomial model has been employed for analysis to investigate the proximity of each dimension and the interaction among them in China's cross-regional collaborative innovation. The results show that China's inter-regional industry-university collaborative innovation follows the "core-periphery" structure. Cooperation between developed and underdeveloped regions is still the dominant synergy model, that’s to say economic distance facilitates the inter-regional collaborative innovation. Despise the development of transportation and communication facilities, geographical distance is still the constraint element for inter-regional collaboration. Different from the linear relationship in previous studies, institutional distance and inter-regional collaborative innovation show an inverted u-shaped relationship. Cognitive proximity significantly promotes cross-regional collaborative innovation and plays the most important role in multi-dimensional proximity.