Abstract:Since its return to China, Macao has made great progress in scientific and technological innovation, gradually increasing investment in scientific research, emerging high-level research and development achievements, and rapid development of innovative science and technology industry. As a typical international free port and one of the four core cities in the Great Bay area, Macao has a historical and extensive connection with the global market, especially Portuguese speaking countries. Its economic operation mode and business operation rules are in line with international practices, which plays an important role in promoting the efficient allocation of innovative resources and building an international scientific and technological innovation center in Guangdong, Hong Kong and Macao. However, there are also some problems in Macao's scientific and technological innovation and achievement transformation, such as insufficient land resources, single industrial structure and insufficient high-end innovation resources. In the next step, Macao should be positioned as an important fulcrum of Guangzhou Shenzhen Hong Kong Macao science and technology innovation corridor, a base for transformation of scientific and technological innovation achievements in the West Bank of the Pearl River Delta, and an important platform for scientific and technological exchange and cooperation between China and Portugal, so as to create a social atmosphere to encourage scientific and technological innovation and to pool scientific and technological innovation resources, so as to further play its role in the construction of the international science and technology innovation center in Guangdong, Hong Kong and Macao Use. Guangdong should further improve the mechanism of cross-border scientific and technological innovation cooperation between Guangdong and Macao, join hands with Macao to gather domestic and foreign high-end scientific and technological innovation resources to transform in the bay area, promote the construction of Guangdong Hong Kong Macao Bay area into a comprehensive national science center and regional innovation highland, and form an International Science and technology innovation center, so as to make the bay area an important power source leading the high-quality development of the whole country.