Abstract:Innovation infrastructure is one of the important links to promote the innovation and development of the country and the city.This paper takes 291 cities at prefecture level and above as the research object, and divides the evolution stage of innovation infrastructure according to the data from 1995 to 2018.This paper selects the data of 2010 and 2018, uses ArcGIS and geoda to analyze the spatial distribution characteristics of innovation infrastructure, and constructs a regression model to analyze the factors affecting the distribution of innovation infrastructure.The results show that: ①According to the development situation, China's innovation infrastructure can be divided into the initial development stage from 1995 to 2010 and the rapid development stage after 2010.②There is path dependence in the spatial distribution of major science and technology infrastructure, and the overall distribution is H-shaped.Science and education infrastructure has evolved from Beijing as the single core to the "Beijing Shanghai" dual core, with Wuhan, Nanjing and other cities as the sub core.The industrial technology innovation infrastructure forms a dual core symbiotic structure of "Beijing-Tianjin", "Shanghai-Hangzhou" and "Guangzhou-Shenzhen".③The spatial distribution of innovation infrastructure has a certain agglomeration phenomenon, but the agglomeration degree is low, which is in line with the distribution law of Hu Huanyong line. It is mainly concentrated in the developed cities in Beijing, Tianjin, Hebei, Yangtze River Delta and some provinces, and the driving role of the eastern core cities is strong.④In general, policies and innovative enterprises have the greatest impact on innovation infrastructure, followed by innovative talents and financial development level.The impact of economic development level and opening up level on innovation infrastructure depends on different economic development modes.The research results deepen the theoretical understanding and provide an important basis for how to lay out the innovation infrastructure in the future.