Abstract:To explore how industrial agglomeration and market competition work together in enterprise innovation, based on the China Industrial Enterprise Database and CSMAR Database, this paper uses a two-way fixed-effect model to test the moderating effect of market competition on the impact of industrial agglomeration in the path of enterprise innovation output, and the regulatory effect is verified by the case of the biomedical industry innovation and development in the Guangdong-Hong Kong-Macao Greater Bay Area. The results show that market competition has a negative regulatory effect on industrial agglomeration and incentives for enterprise innovation, and it only exists in technology-intensive industries; the market monopoly of state-owned enterprises will weaken the innovation-promoting effect of industrial agglomeration. Considering the heterogeneity of industries and enterprises, giving full play to the interactive effects of market competition and industrial agglomeration is an important way to enhance the innovation capabilities of enterprises. To this end, policy recommendations such as accelerating the cultivation of advanced manufacturing clusters, vigorously cultivating leading enterprises in the industry, and accelerating the classification reform of state-owned enterprises have been proposed.