Abstract:Based on the introduction of the governance philosophy, organizational model and management system of the McGovern Institute for Brain Research, and semi-structured interviews mainly with the researchers of the three McGovern Institute for Brain Research jointly established in China, the analysis concludes that researchers are most concerned about the scientific research review mechanism, funding support mechanism and the construction of the scientific research soft environment of a Frontier Science Center . Drawing on the experience of McGovern Institute for Brain Science, it is recommended that research universities in China should focus on recruiting top talents to participate in the construction of the frontier scientific research platform supported by substantive organizational models, providing stable scientific research supports and diversifying funding sources, enhancing international exchanges and cooperation, encouraging interdisciplinary research, building a soft environment for collaborative innovation, and improving international management.