Abstract:With the increasingly obvious trend of globalization, the cooperation and exchange of scientific and technological talents can effectively promote the transfer and transformation of technology to a certain extent. This paper analyzes the cooperation and exchange of scientific and technological talents in Guangdong, Hong Kong and Macao and its role in promoting the transformation of technology transfer, finds that the current cooperation between scientific and technological talents in Guangdong, Hong Kong and Macao has problems such as a single way of team cooperation and communication, the shortage of professional technology transfer and transformation talents. Combined with the urgent needs of the current scientific and technological innovation and development of Guangdong province, the paper proposes to vigorously carry out cooperation and exchange of scientific and technological talents in Guangdong, Hong Kong and Macao, support multidisciplinary and cross-field teamwork, establish talent sharing and flexible employment mechanism, and cultivate professional technology transfer and transformation talents.