Abstract:New research and development (R D) institutions in universities are an innovative form of in-depth cooperation between industry, university and research. As an important part of the national innovation system, their development reflects the training logic of new high-end talents. Based on the talent cultivation of new R D institutions in universities from the niche theory perspective, with the goal of understanding theory, scientific research, and the market, through the construction of a "dual tutor" guidance system for scientific research and market, improving the teaching and training system and perfecting the graduation assessment system, the new R D institutions in universities give full play to the role of “Industry-University-Research”. The students are cultured as high-end innovative talents with new characteristics who are proficient in theory, good at research, and familiar with industry, further better solve the phenomenon of college talent training and market talent demand, and provide high-quality talents for the implementation of the national innovation-driven development strategy.