Abstract:This paper studies the development of family business, and uses the data of Chinese listed family enterprises from 2007 to 2016 to explore the influence of family business de-family on enterprise R&D investment and the adjustment effect of two power deviation and regional marketization process. The results show that the change of the actual controller and the introduction of external professional managers in the family business will significantly inhibit the innovation investment of the enterprise; the deviation of the two powers has no significant adjustment effect on the suppression relationship between de-familyization and enterprise innovation investment; regional marketization process Will significantly weaken the relationship between family and corporate innovation investment.