Abstract:Guangdong key laboratory is an important component of the innovation system of Guangdong province and an important component for basic and applied basic research. Based on the sample of 197 Guangdong key laboratories from 2013 to 2018, the samples were divided into four groups, namely, universities, hospitals, research institutes and enterprises in consideration of the value-oriented role of the subject. On the basis of combing the indicators of previous literature studies, this paper establishes four evaluation system, namely, talent team, academic research, innovative research, and achievement transformation, and analyzes input-output efficiency of four groups samples by using CCR and BCC. The research results show that the efficiency characteristics of the four groups of samples under different index systems are significantly different. Talent team is the main factor that affects the input-output efficiency of academic research in universities and hospitals. Research project funding is the main factor that affects the input-output efficiency of enterprises and research institutes. In order to provide a new perspective for the rational evaluation of the innovation efficiency of various scientific research platforms in Guangdong Province, this paper also proposes a grouping evaluation method based on different evaluation orientations.