Abstract:The paper constructs a theoretical framework of "four chain" integration development, which can not only reflect the power source of global science and technology innovation center, but also coordinate the relationship between innovation elements and innovation environment.This is a new paradigm of cross organizational symbiotic collaborative innovation. Its core is the “four chains” composed of science and technology oriented industry chain, science and technology innovation chain, science and technology fund chain, and science and technology service chain. Through mutual integration and interaction of the “four chains”, it can optimize the innovation ecosystem and improve the efficiency of regional innovation ,furthermore collaboratively build a high-level global science and innovation center. Based on this theoretical framework, and judgment of realistic foundation and restrictive factors, this paper puts forward some Suggestions on how to build an global science and technology innovation center in Guangdong-Hong Kong-Macao Greater Bay Area.