Abstract:In digital context, business model innovation is the only way for pharmaceutical companies. First, This paper conducts exploratory case study method on the leading company of pharmaceutical industry, starting from two aspects in resource and channel; Second, the paper summarizes three different business models from different scenarios, and analyzes the key behaviors of companies and stakeholders from a perspective of digital technology, and sums up the core mechanism of digital technology-driven business model innovation;At last, the paper summarizes the path of pharmaceutical companies’ business model innovation with the help of the NICE attributes framework(i.e. the attribute framework composed of novelty (N), lock-in (I), complementarity (C) and efficiency (E)) to guide pharmaceutical companies to achieve the success of business model transformation and upgrading in Chinese context.