Abstract:The implementation of innovation driven development strategy needs a large number of scientific and technological talents, so it is necessary to estimate the demand of scientific and technological talents. This paper selects the full-time equivalent data of national R & D personnel (excluding Hong Kong, Macao and Taiwan) in China Statistical Yearbook (1999-2020), constructs the grey GM (1,1) prediction model based on the data from 2012 to 2019, and constructs the time series model based on the data from 1995 to 2019 to forecast the total demand of scientific and technological talents in China during the "14th five year plan". The forecast results show that the demand for scientific and technological talents is increasing year by year during the "14th five year plan" period, and the full-time equivalent demand scale of scientific and technological talents reaches 6.4746 million person years. Based on the prediction results, this paper thinks that we should pay attention to the demand and supply of scientific and technological talents, and ensure the accumulation of scientific and technological talents, quality improvement and full utilization from the aspects of talent planning, training, management and use.