Abstract:In recent years, local governments have cooperated with universities to set up a number of new R & D institutions with modern management system, market-oriented operation mechanism and flexible employment mechanism. Based on the case study of Guangdong, Fujian and Jiangsu Province, this paper extracts the core factors influencing the innovation effect: local government innovation conditions, parent university innovation conditions, innovation ability, university cooperation and dual innovation network characteristics. Through the qualitative comparative analysis based on fuzzy sets, various configurations leading to high innovation effectiveness are obtained. It is found that among the influencing factors, centrality of technological innovation network, innovation ability and cooperation between colleges and universities are the necessary conditions, and all kinds of typical configurations play an important role through innovation network. Finally, policy suggestions and measures are put forward.