Abstract:As new form of regional innovation development, science and technology innovation corridor plays an important role in the aggregation of innovation elements and the construction of regional innovation network. At present, the construct of science and technology innovation corridor is becoming the strategic focus of regional exploration and innovation practice and regional governance in China. However, the connotation and boundary of science and technology innovation corridor are still to be clarified, and its basic concept and boundary scope need to be considered. Under the premise of horizontal comparison of different forms of regional innovation and development, this paper considers the essential connotation of science and technology innovation corridor, and considers that it is a special regional innovation and development mode that carries out the innovation process completely. This study further analyzes the cases of science innovation corridors at home and abroad, and determines the boundaries of science and technology innovation corridors from the perspective of knowledge. It is believed that the geographic space of organizations participating in innovation activities in science and technology innovation corridors is the physical boundary, innovation activities are the virtual boundary, and science and technology innovation is the development orientation. This study provides the concept guidance for the planning and construction of science and technology innovation corridor, and promotes its high-efficiency, high-resource utilization and high-benefit development.