Abstract:Based on the panel data of 30 provinces (cities, municipalities) in China from 2009 to 2018, this paper uses entropy method, coupling model and static panel model to calculate the coupling degree between sci-tech finance and industrial structure upgrading,analyzing its influencing factors. The conclusions are as follows: (1) the coupling degree between sci-tech finance and industrial structure upgrading is on the rise as a whole, but there are obvious differences among regions, and the average coupling degree gradually decreases from east to west; (2) Government investment, financial institution loan, technological innovation ability and regional industrial structure can significantly improve the coupling degree between them; the loan strength of financial institutions, the level of economic development and the regional industrial structure have the greatest influence on the coupling degree of the two in the eastern, central and western regions. It is suggested that we should give full play to the positive role of public sci-tech finance, adhere to technological innovation and attach importance to the cultivation of innovative talents, so as to improve the coupling degree between sci-tech finance and industrial structure upgrading and realize high-quality economic development.