Abstract:[Purpose/Significance] At present, the cross-fusion of safety informatics and cognitive science is tending to develop, but the theory of safety information cognition has not been established yet. Therefore, based on the perspective of subject construction, this paper carries out theoretical research on subject construction of safety information cognition. [Process/Method] At first, based on the characteristics of interdisciplinarity, safety science, information science, cognitive science, on the basis of safety information is given the definition and connotation of cognitive science, the discipline nature, then expounds the theoretical basis of safety information cognitive science and its research contents, research methods, constructing basis, branch and classification, the application prospect of subjects such as basic issues, for the safety information of cognitive science to provide constructive framework. [Results/Conclusions] The results show that safety information cognition has a solid theoretical basis in construction, and has a broad application prospect in accident prevention and wisdom safety.