Abstract:The construction of national medical S&T (science and technology) innovation system in China is the important pathway to improve the innovation performance, to promote the formation of innovation ecosystem, and ultimately support the improvement of people’s health status and the competitiveness of the pharmaceutical industry. Presently, the national medical S&T innovation system has been proposed and need further being constructed by theoretical promotion. Based on the theory of innovation system, the framework of national innovation system in China and the sect-oral characteristics of medicine, this study proposed the structural framework of national medical S&T innovation system, which includes three layers, i.e., the layer of innovation actors, of the development conditions and of the system targets. Besides, we investigate and elaborate the corresponding innovation actors, the function of innovation system, the driving factors and the ecosystem environment, which may provide the theoretical support for further construction of national medical S&T innovation system in China.